Affinity DataKi: 1nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Z-Leu-Leu-Leu-al as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: 487nMAssay Description:Binding affinity to human 20S constitutive proteasome beta 2 subunit assessed as equilibrium constant using fluorogenic peptide Ac-WLR-AMC as substra...More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Affinity DataKi: 4.38E+3nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Affinity DataKi: 5.52E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Z-Leu-Leu-Leu-al as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 5.52E+3nMAssay Description:Inhibition of 20s constitutive proteasome beta2 trypsin-like activity in human erythrocytes using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by f...More data for this Ligand-Target Pair
Affinity DataKi: 5.57E+3nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
Affinity DataKi: 6.71E+3nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+4nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Inhibition of 20s constitutive proteasome beta2 trypsin-like activity in human erythrocytes using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by f...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 2.21E+4nMAssay Description:Competitive inhibition of trypsin-like activity of human 20S proteasome using Boc-Leu-Arg-Arg-AMC as substrate measured for 10 mins by fluorescence a...More data for this Ligand-Target Pair
Affinity DataKi: 4.20E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 4.20E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 5.10E+4nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: 2.90E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: >4.50E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: >4.50E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: >9.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataKi: >9.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 0.920nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of 20S proteasome (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair